Npgrj_ng_1589 1..8
نویسندگان
چکیده
A key goal of biomedical research is to elucidate the complex network of gene interactions underlying complex traits such as common human diseases. Here we detail a multistep procedure for identifying potential key drivers of complex traits that integrates DNA-variation and gene-expression data with other complex trait data in segregating mouse populations. Ordering gene expression traits relative to one another and relative to other complex traits is achieved by systematically testing whether variations in DNA that lead to variations in relative transcript abundances statistically support an independent, causative or reactive function relative to the complex traits under consideration. We show that this approach can predict transcriptional responses to single gene– perturbation experiments using gene-expression data in the context of a segregating mouse population. We also demonstrate the utility of this approach by identifying and experimentally validating the involvement of three new genes in susceptibility to obesity.
منابع مشابه
Npgrj_ng_1589 710..717
A key goal of biomedical research is to elucidate the complex network of gene interactions underlying complex traits such as common human diseases. Here we detail a multistep procedure for identifying potential key drivers of complex traits that integrates DNA-variation and gene-expression data with other complex trait data in segregating mouse populations. Ordering gene expression traits relat...
متن کاملSupplement to Internally 4-connected projective-planar graphs
A5 = {{1, 2}, {1, 3}, {1, 4}, {1, 5}, {2, 3}, {2, 4}, {2, 5}, {3, 4}, {3, 5}, {4, 5}, {6, 7}, {6, 8}, {6, 9}, {6, 10}, {7, 8}, {7, 9}, {7, 10}, {8, 9}, {8, 10}, {9, 10}} C11 = {{1, 2}, {1, 3}, {1, 4}, {1, 5}, {2, 3}, {2, 4}, {2, 5}, {3, 4}, {3, 5}, {4, 5}, {6, 9}, {6, 10}, {6, 11}, {7, 9}, {7, 10}, {7, 11}, {8, 9}, {8, 10}, {8, 11}} E42 = {{1, 4}, {1, 5}, {1, 6}, {2, 4}, {2, 5}, {2, 6}, {3, 4},...
متن کامل4.3 Modiied Variants and Weaknesses 4 the Attack on Lucifer 3 Conditional Characteristics
Round output diierence input diierence p icb key fraction P = (f7g; 0) 1 A = 0 a = 0 1 1 2 B = f45g b = f7g p = 1=8 0 1/2 3 C = f6g c = f45g p = 1=8 1 1/2 4 f45g f6; 7g p = 1=8 0 1/2 5 0 0 1 1 6 f45g f6; 7g p = 1=8 0 1/2 7 f6g f45g p = 1=8 1 1/2 8 f45g f7g p = 1=8 0 1/2 9 0 0 1 1 8 f39g f7g p = 1=8 1 1/2 9 f7g f39g p = 1=8 1 1/2 T = (0; f39g) 17 ent fractions of the key space. Round output diie...
متن کامل(Mart\355nez Mendoza, S. \(2007\)...)
7 ! +, %.3, , 8 5 1 & , 93 3 1 : 1 , . , , . , ;; + 3 1 : / 93 . 1 . / ! < %.3, 93 , . , 8 . / . 3 , , . ;01, . ; , . / 5 / . ' , = 1 > : , . , 8. . > , 3 . /, , . , .. , & ' 1 8 . . , . ' , 1: > , 3 3 ,% 1 : 93 1 , . 3 . . / 8. . . % > , ., = , , 93 . . & , %.3, > 93 5 . 8, 3 , .. / 3. 93 , 93 . , . . / , . ;01, . !! < %.3, 93 . 3 / , . , . , . 01, . > 3 2, , . , 8. . 3 . / , . . .. . 3 . . / ...
متن کاملProbabilistic Name and Address Cleaning and Standardisation
! " $#% '&"( ) *+ ,$ . / 10 " 23 4 / ,5 $ 4 6 *7 6 / 1 8 9 : ; ,8 #< = > ! /*? 8 2 = @ / 1 A B1 4 < = *@ 4 8 CD FEG 1 ,H&I )EG < *J ,8 8 C = 7EK D 8 5*@ 8,8 8 CJ,8 L ( > 8 G 9 / M*@ "&7,8 0 C H 8 ,N '2 *7 8 ,C/ 8 ,M ' G ,H ,L 1 ' A OP 9 ,H&"(Q *7 J R S > 9 R 2 6 / 10 L = = R RT/ &1 C; 9 *@ (K ,8,H® H U /*7 1 '0 C < + 23 ',-,8 8 CU V W&123 /C = 2 8 ,F 4 AX Y 8 ' ' Z 8*723 = " + 4 R = ) 8 + = ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2005